• br Vertebrate steroid receptor evolution br Conclusion The t

  2021-09-29

  

  Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th

• AdipoRon Inflammatory pain is very common in

  2021-09-28

  

  Inflammatory pain is very common in the clinic. A study demonstrated that galanin was upregulated after nerve injury or inflammation (Ma and Bisby, 1997). It has been reported that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflamma

• Dysregulation of the HPA axis resulting

  2021-09-28

  

  Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba

• Mammalian CAPS includes two i http www apexbt com media

  2021-09-28

  

  Mammalian CAPS includes two isoforms, CAPS-1 and CAPS-2. Both isoforms contain several functional domains, including a C2 domain that is likely responsible for CAPS dimerization (Petrie et al., 2016), a pleckstrin homology (PH) domain that binds PIP2 (phosphatidylinositol 4,5-bisphosphate) and media

• Biliary tract cancers BTC are categorized into intrahepatic

  2021-09-28

  

  Biliary tract cancers (BTC) are categorized into intrahepatic, perihilar, extrahepatic BTC (or cholangiocarcinoma) as well as gallbladder cancer (GBC). Although the incidence of BTC is low in developed countries (3% of gastrointestinal cancers), BTC is the second most common primary liver tumor afte

• br Although there are growing bodies

  2021-09-28

  

  Although there are growing bodies of research dealing with diverse non-imidazole based compounds, they are not free from obstacles in their development pipeline and hence the design of these compounds is complicated by various factors briefly discussed below. One of the problems in designing H3R a

• In our study we found that HER

  2021-09-28

  

  In our study, we found that HER2-mutant lung cancers occurred commonly in female patients with an advanced stage at time of diagnosis and in a relatively younger age group. Previously, Mazières et al. [8] obtained comparable epidemiological findings, including a median age of 60 years, a high propor

• Acknowledgement This work was supported by

  2021-09-28

  

  Acknowledgement This work was supported by grants from the National Natural Science Foundation of China (No.81802749), Shenzhen Healthcare Research Project (No.SZBC2017029), the Science and Technology Foundation of Shenzhen (JCYJ20170412155231633, JSGG20170414104216477), National Key Research and D

• br Activation of soluble guanylate cyclase

  2021-09-28

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• br Materials and methods br Results

  2021-09-28

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic pmsf mg is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate cancer. However,

• In the present study we aimed

  2021-09-28

  

  In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA diacylglycerol kinase of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs. l

• crf1 It is well known that the expression of

  2021-09-28

  

  It is well known that the expression of GPR109A is regulated under physiological and pathological conditions. We previously found that GPR109A expression in islet beta-cells increased with age and was up-regulated by interferon-γ (Li et al., 2011). GPR109A levels in Min6 and INS-1E islet beta-cells

• Until now unfortunately no safe effective vaccine against HI

  2021-09-28

  

  Until now, unfortunately, no safe, effective vaccine against HIV-1/AIDS has been found [16], [17]. Therefore, the development of safe, effective vaccines is a top priority in HIV/AIDS research field. Accordingly, to investigate the interactions between HIV vaccines or inhibitors and their correspond

• br Introduction The alternative splicing of pre mRNA

  2021-09-28

  

  Introduction The alternative splicing of pre-mRNA is essential for generating multiple matured mRNAs from a single gene by selectively removing introns. Neural Fmoc-Gly-OPfp show many examples of regulated alternative splicing events, which produce structural changes in proteins important for th

• INNO-406 br Conclusions Temporally controlled disruption of

  2021-09-28

  

  Conclusions Temporally-controlled disruption of Gcgr reveals a lack meaningful contribution to the improvement of glycemic control in insulinopenic conditions attributable to the intrinsic loss of GCGR signaling. On the other hand, these data highlight the importance of compensatory systems, incl

13664 records 518/911 page Previous Next First page 上5页 516517518519520 下5页 Last page