• Our aim was to gain insight into

  2021-11-30

  

  Our aim was to gain insight into mechanisms that underlie the contribution of thrombospondin-1 (TSP1) to progression of CKD. TSP1 is the most-studied member of the thrombospondin family of matricellular proteins. Previous studies have demonstrated that pharmacological suppression or genetic depletio

• The soluble receptor for advanced glycation end products has

  2021-11-29

  

  The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE

• In Locusta migratoria a worldwide agricultural pest we previ

  2021-11-29

  

  In Locusta migratoria, a worldwide agricultural pest, we previously identified 51 CPRs containing eight endocuticle structural glycoproteins, which are homologs of SgAbd-1, SgAbd-2, SgAbd-3, SgAbd-4, SgAbd-5, SgAbd-6, SgAbd-8, and SgAbd-9 in the adult desert locust, Schistocerca gregaria [17,26]. Al

• br Genetic rescue of GluR A

  2021-11-29

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific clobetasol price mg of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al.,

• It is increasingly argued that the immunosuppressive

  2021-11-29

  

  It is increasingly argued that the immunosuppressive effects of GCs are conferred indirectly by GR through the activation of genes encoding proteins that inhibit trp channel of proinflammatory genes 86, 87, 88. Genomic studies offer another mechanism compatible with the idea that GC-mediated repress

• AKR D is very highly expressed in human liver

  2021-11-29

  

  AKR1D1 is very highly expressed in human liver and based upon the observations outlined above, with respect to other steroid hormone pre-receptor metabolising enzymes, it is entirely plausible that AKR1D1 could represent a critical regulatory step in the control of metabolic phenotype within the liv

• It is generally considered that elevated blood glucose

  2021-11-29

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet p53 inhibitor in the

• br Voltage dependent anion channel

  2021-11-29

  

  Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially

• Based on the collective experience to date it is

  2021-11-29

  

  Based on the collective experience to date, it is likely that a much more comprehensive assessment of GSI selectivity for inhibition of multiple substrates, as well as biomarkers to track inhibition of non-APP substrates in vivo will be needed to support future efforts to develop substrate selective

• 4-HQN mg The significance of A and

  2021-11-29

  

  The significance of Aβ and tau as therapeutic targets is not only derived from pathological evidence of postmortem brain but also from biochemical analysis of cultured human neurons. This is largely based on the induced pluripotent stem cell (iPSC) technology that has been established to study Aβ, t

• The current study aimed to understand the roles and

  2021-11-29

  

  The current study aimed to understand the roles and the underlying mechanisms of XIST in LSCC, by focusing on the regulation by miR-124-3p, which was previously identified as a target of XIST [12]. We found that the XIST expression is positively correlated with the stages of LSCC in patients. Knockd

• br Conclusions In summary our results demonstrate that in

  2021-11-29

  

  Conclusions In summary, our results demonstrate that in short term effect, TBT induced concentration-dependent vasorelaxation of HUA rings. Regarding the long term effects, exposure to a concentration of 100 μM TBT the human umbilical Ac-IETD-pNA have a dual effect, and a decrease of the 5-HT2A e

• To prevent toxicity of free hemoglobin as well as

  2021-11-29

  

  To prevent toxicity of free hemoglobin as well as its degradation metabolites heme and free iron, several scavenger proteins and degradation enzymes protect the body. Haptoglobin (Hp) is the most well described hemoglobin scavenging protein that binds free hemoglobin and transports it to macrophages

• Furthermore the identification of the

  2021-11-29

  

  Furthermore, the identification of the inhibitory effect of P. grandiflorum and ginseng extract on HDAC represents an effective workflow for gene expression similarity-based repositioning of nutraceuticals. Acknowledgments This research was supported by Basic Science Research Program through the

• Stimulation of GC A by CNP was further

  2021-11-29

  

  Stimulation of GC-A by CNP was further corroborated by using a cGMP enzyme immunoassay. We could show that CNP significantly stimulated cGMP synthesis in the GC-A reporter cell line. CNP stimulation resulted in similar maximal cGMP levels compared to stimulation by ANP and BNP. Therefore, by lumines

13983 records 503/933 page Previous Next First page 上5页 501502503504505 下5页 Last page