• According to its major function as master

  2022-03-21

  

  According to its major function as master regulator of BA homeostasis, FXR has been shown to have a specific tissue distribution; it is expressed along the entire gastrointestinal tract with a peak in the liver and ileum, as well as in the kidney, and adrenal glands [30], [66], [135]. Low FXR expres

• br Declaration of interest br Acknowledgments br

  2022-03-18

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• The Rho family of GTPases is

  2022-03-18

  

  The Rho family of GTPases is composed of many small ubiquitous signaling G proteins that bind to guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). They act as switches: when binding to GTP, they are active and associate with a variety of target proteins that regulate intr

• br Conclusions and perspectives In conclusion

  2022-03-18

  

  Conclusions and perspectives In conclusion, offering duly validated and highly performing assays for measuring DiXaIs in plasma is a step, but not the final issue. More dedicated and individual assays will continue this innovative development, which witnesses the need for collaboration between co

• Hyperactivation of Notch pathway can give

  2022-03-18

  

  Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap

• cytochalasin d br Acknowledgement This research was supporte

  2022-03-18

  

  Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1A2B4012818). Oral cytochalasin d is the most popular administration route due to good patients’

• The combination of HIV antigen and antibody

  2022-03-18

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window angiotensin ii causes for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo

• br Introduction Ovarian cancer patients have the highest mor

  2022-03-18

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is 98059 with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation in carcinogene

• All of the designed compounds

  2022-03-18

  

  All of the designed compounds – was synthesized from -cyclopropane aldehyde , which was prepared following a procedure we reported previously. Treatment of with 4-chlorobenzene-1,2-diamine in pyridine constructed benzimidazole structure of , which was subjected to deprotection and subsequent oxidati

• Miltefosine HO acted as an intracellular

  2022-03-18

  

  HO-1 acted as an intracellular defender against oxidative stress-induced cell damage. To elucidate the effects of HO-1 in ropivacaine-induced cytotoxicity in neuronal cells, HO-1 activity was inhibited using a specific HO-1 inhibitor zinc protoporphyrin, ZnPP. Our results indicate that ZnPP treatmen

• Interestingly in vivo infusion and uptake of Ang

  2022-03-18

  

  Interestingly, in vivo infusion and uptake of Ang II in intact mice indicated that multiligand endocytic receptor megalin has at least some role in the uptake of Ang II and the downstream signaling process in proximal tubule leukotriene receptor antagonists (PTCs) in vivo [173]. Earlier in vivo stu

• ipatasertib In the present study we

  2022-03-18

  

  In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c

• We previously evaluated the immuno

  2022-03-18

  

  We previously evaluated the immuno-modulatory efficacy of GSNO in different EAE models and reported prophylactic and therapeutic efficacy of GSNO against the clinical disease of EAE [22], [36]. GSNO inhibited the IL-6-induced STAT3 activation (Tyr705 phosphorylation) by S-nitrosylation of the STAT3

• br GPR GPR has been described as a

  2022-03-18

  

  GPR55 GPR55 has been described as a type 3 cannabinoid receptor due to its ability to detect endocannabinoids and may play a role in the endocannabinoid lipid sensing system [28]. GPR55 is activated by both cannabinoid endogenous agoinsts (endocannabinoids) and non-cannabinoids fatty acids namely

• Some biguanides can cross the mitochondrial membrane

  2022-03-18

  

  Some biguanides can cross the mitochondrial membrane and increase L-lactate formation by inhibiting oxidative Plumbagin receptor [34]. On the other hand, it has also been reported that levels of fasting plasma lactate in T2DM patients are similar regardless of whether or not metformin is administer

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