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This evidence suggests that the human cochlea is equipped
2022-04-18
This evidence suggests that the human cochlea is equipped with antigen presenting macrophages as well as T lymphocytes that execute cytotoxic and immune mediation function. In an animal study, following acoustic overstimulation, Yang et al. (2015) found infiltration of macrophages into the region of
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The amyloid precursor protein APP is a membrane protein thou
2022-04-18
The amyloid precursor protein (APP) is a membrane protein thought to be involved in plasticity, synapse formation and repair, and export of metal ions [68]. The APP present in the brain can be cleaved by three different secretases [73], [74]. Cleavage of APP first by alpha secretase and then gamma-s
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The association between mental disorders and
2022-04-18
The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi
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ICH induced striatal lesion produced a
2022-04-18
ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino ucf101 transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (Rao
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br Acknowledgements br Introduction Protein translation dema
2022-04-18
Acknowledgements Introduction Protein translation demands high fidelity. There are number of molecular checkpoints to fulfill this demand. Among these, insuring that a particular tRNA gets aminoacylated by its conjugate amino acid, which in turn is catalyzed by a particular aminoacyl-tRNA synt
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br Methods br Results Top panels of the Fig
2022-04-18
Methods Results Top panels of the Fig. 1 show the conventional representation of the predicted values of TL,CO according to ERS’93 and GLI′17 as a function of age and keeping the height constant (160 cm, panel A and 190 cm, panel B). This figure shows that the GLI-‘17 predicted values of TL,CO
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The stability of the i motif at the
2022-04-18
The stability of the i-motif at the neutral pH has been analyzed in our previous paper [31] by tracking the rmsd changes in unbiased calculations. Fig. 7 presents, just to confirm the conclusions drawn in [12], the changes in distances between atoms forming hydrogen bonds within the i-motif structur
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Sweroside australia Acknowledgments This work was supported
2022-04-18
Acknowledgments This work was supported by the Natural Science Foundation of China (Nos. 21602254, 81603194), the Natural Science Foundation of Jiangsu province, China (BK20160767) and National Found for Fostering Talents of Basic Science (NFFTBS, J1310032). Introduction Glucocorticoids (GC) pl
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Occupying at least of brain volume astroglial cells not only
2022-04-18
Occupying at least 50% of Ac-IETD-AFC volume, astroglial cells not only possess a high level of association in network through gap junctions and direct intercellular communications [28], but also are extensively exposed to extracellular fluid and contribute in shaping different types of synapses [2
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The third group also included
2022-04-16
The third group also included samples belonging to subjects with undetectable viraemia, for which the negative or persistence of the indeterminate WB result in subsequent samples indicated a non-HIV infection. In this subgroup, the VITROS HIV Combo test (as well as the other two tests) was negative
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The comparatively low number of H R agonists is contrasted
2022-04-16
The comparatively low number of H1R agonists is contrasted by the high number of diverse H1R antagonists. Based on pharmacological classification, they are grouped into different generations by considering their target as well as side effects profile. The first generation “antihistamines” consist of
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H R antagonism can prevent seizure development and improve w
2022-04-16
H3R antagonism can prevent seizure development and improve working memory through the activation of histaminergic neurons (Huang et al., 2004, Zhang et al., 2003). In addition, we have recently found that H3R antagonism protects against ischemia-reperfusion injury via histamine-independent mechanism
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It was speculated that could affect
2022-04-16
It was speculated that could affect the protein translation or processing in the HCV replication cycle. The viral protein processing was thus investigated, to establish whether the HCV inhibition was determining an increased amount of unprocessed polyprotein, due to a block in the processing, or a
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In contrast to sGC stimulators sGC activators promote enzyma
2022-04-16
In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading
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br Material and methods br Results and discussion Unlike man
2022-04-16
Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of Nucleozin mg biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called non-clima
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