• br Acknowledgments This work was supported by the

  2025-01-15

  

  Acknowledgments This work was supported by the Swiss National Science Foundation. 15-Lipoxygenase 1 (15-LOX-1) is a nonheme, iron-containing enzyme predominantly expressed in reticulocytes, eosinophils, macrophages, mast cells, and bronchial epithelial cells . 15-LOX-1 is a key enzyme involved

• A large number of studies have shown that

  2025-01-15

  

  A large number of studies have shown that oxidative stress is involved in the pathophysiological process of ventricular remodeling and is associated with left ventricular dysfunction (Hori and Nishida, 2009, Lord et al., 2010). The generation of reactive oxygen species (ROS) that exceeds anti-oxidat

• This development notwithstanding the chemotherapeutic treatm

  2025-01-15

  

  This development notwithstanding, the chemotherapeutic treatment for leukemia has stagnated over the last 40 years [35]. Main treatment options necessitate aggressive chemotherapy to target leukemic cells [36], [37], [38], [39]. Several limitations of current treatment options include the use of ant

• The direction of research then turned to investigating

  2025-01-15

  

  The direction of research then turned to investigating the long-term effects of adiponectin on insulin resistance. Adiponectin transgenic mice showed a reduction in insulin resistance and diabetes [5,6], while adiponectin-deficient mice showed mild insulin resistance with glucose intolerance, as wel

• It is worth mentioning that cordycepin as an adenosine

  2025-01-14

  

  It is worth mentioning that cordycepin, as an adenosine analogue, is structurally similar to adenosine. A previous study has shown that the anti-apoptotic effects of cordycepin are partially dependent on the activation of A1R [16], and cordycepin increases theta waves power density via nonspecific a

• A borderline significant effect of women

  2025-01-14

  

  A borderline significant effect of women's age has been observed for ADA6 only. For ADA2 the proportion of the *1/*1 genotype is 69.4% in women aged ≤36 years vs. 66.9% in women aged ≥36 years (p=0.944). The proportion of ADA6*1 allele carriers is 32.6% in women aged ≤36 years vs. 49. 8 in women age

• Actin is capable of polymerizing spontaneously However this

  2025-01-14

  

  Actin is capable of polymerizing spontaneously. However, this process is relatively slow and kinetically unfavorable in cells. Formation of KN-93 dimers and trimers, which can easily disassemble due to their instability, is a rate-determining step in actin polymerization [5], [6]. The shape and the

• Sperm total motility and hyperactivated motility are mediate

  2025-01-14

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent Caspase-3, human recombinant proteinase australia polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm

• Because serum ATX activity and plasma LPA are well correlate

  2025-01-14

  

  Because serum ATX activity and brexpiprazole drug class LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, L

• α-Cyperone Calcineurin has been established to be a

  2025-01-14

  

  Calcineurin has been established to be a ubiquitous Ca2+-activated serine phosphatase in the nervous system (Pyrzynska et al., 2001). It has been reported that the activation of calcineurin protects aromatase from autophagy-mediated protein degradation, implying that calcineurin-dependent dephosphor

• br Abbreviations br Acknowledgements This work was supported

  2025-01-14

  

  Abbreviations Acknowledgements This work was supported by grants from the National Institutes of Health (R01GM114168) and the Office of Naval Research (N000141210773) awarded to J.C·H and National Cancer Institute (5P30CA16059) Cancer Center Support Grant in support of Massey Cancer Center Pro

• br Introduction AMPA receptors AMPARs mediate the

  2025-01-13

  

  Introduction AMPA receptors (AMPARs) mediate the majority of fast excitatory postsynaptic currents (EPSCs) in the FTI 277 HCl (Jonas, 2000). The brevity of EPSCs and rapid deactivation of AMPARs depend upon a short lifetime of synaptically released glutamate, estimated to be about 1 ms (Clements

• This evidence suggests the strong clinical

  2025-01-13

  

  This evidence suggests the strong clinical relevance of the identification of acquired resistance mechanisms for a proper therapeutic decision in patients with ALK-rearranged NSCLC. When the tissue is not available, the analysis of circulating tumor DNA (cfDNA) can be a valid alternative for the det

• Mechanistically NAergic signaling in the

  2025-01-13

  

  Mechanistically, NAergic signaling in the VTA modulates neuronal activity presumably via α1-AR. The majority of α1-ARs are found in the VTA are located presynaptically on unmyelinated Anticancer compound and axon terminals of glutamatergic and GABAergic neurons. However, α1-ARs are also found on neu

• hydroxydopamine OHDA is a selective catecholaminergic neurot

  2025-01-13

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

13983 records 25/933 page Previous Next First page 上5页 2122232425 下5页 Last page